Global Journalist: Iraq War and the Israeli-Palestinian Conflict

In this Sepember 26, 2002 episode of Global Journalist, host Stuart Loory and four journalists discuss the Israeli-Palestinian conflict and the upcoming war against Iraq. Guests from the US, Palestine, Israel and France discuss how the invasion of Iraq would bring impact to the Arab world and Israel, as the US is making its effort to gain support from European allies to its cause in Iraq

In Vitro Reconstituted Biotransformation of 4-Fluorothreonine from Fluoride Ion: Application of the Fluorinase

SummaryIn this paper, we report that fluoride ion is converted to the amino acid/antibiotic 4-fluorothreonine 2 in a biotransformation involving five (steps a–e) overexpressed enzymes. The biotransformation validates the biosynthetic pathway to 4-fluorothreonine in the bacterium Streptomyces cattleya (Schaffrath et al., 2002). To achieve an in vitro biotransformation, the fluorinase and the purine nucleoside phosphorylase (PNP) enzymes (steps a and b), which are coded for by the flA and flB genes of the fluorometabolite gene cluster in S. cattleya, were overexpressed. Also, an isomerase gene product that can convert 5-FDRP 6 to 5-FDRibulP 7 (step c) was identified in S. cattleya, and the enzyme was overexpressed for the biotransformation. A fuculose aldolase gene from S. coelicolor was overexpressed in E. coli and was used as a surrogate aldolase (step d) in these experiments. To complete the complement of enzymes, an ORF coding the PLP-dependent transaldolase, the final enzyme of the fluorometabolite pathway, was identified in genomic DNA by a reverse genetics approach, and the S. cattleya gene/enzyme was then overexpressed in S. lividans. This latter enzyme is an unusual PLP-dependent catalyst with some homology to both bacterial serine hydroxymethyl transferases (SHMT) and C5 sugar isomerases/epimerases. The biotransformation demonstrates the power of the fluorinase to initiate C-F bond formation for organo-fluorine synthesis

Corporate accountability in a globalizing environment : empirical evidence

For many years, there have been vigorous arguments between supporters of the shareholder and stakeholder models as to which system is more effective in enhancing corporate values and disciplining managements. What view one takes of course very much depends on political viewpoint and national background. For example. economists or lawyers in the US or UK may argue that the Anglo-American shareholder model is more appropriate. This is because there is at least a criterion (i. e. share price) by which you could measure and compare corporate performance. Supporters of the shareholder model may argue that the concept of stakeholder is anticapitalism and that it is too broad and abstract, providing no clear boundary as to who may or may not fall into that category. Yet in contrast, their Japanese or German (and other Continental European) counterparts may argue that the Anglo-American approach of primarily focusing on share value and wealth maximization is too narrow and an over-simplistic view of the role played by corporations. Supporters of the stakeholder theory would argue that it is necessary to take into consideration interests beyond those of shareholders. This is because businesses ought to demonstrate certain responsibilities towards the society in which they operate. This thesis neither supports nor challenges the validity of either the shareholder or stakeholder approach. Instead it attempts to search for a "middle approach". The aim is to bring the concept of both values together to form a corporate governance model based on convergence and co-existence. The main proposal of this thesis is as follows. Living in the twenty-first century, we must understand that our world is neither being Americanized nor Europeanized or Orientalised. We are instead being globalized. National identities in terms of corporations will become less and less important as multinational corporations extend their activities throughout the globe. With the advance in technology and increase in cross-border business transactions amongst countries, it is no longer justified to argue that "one business model fits all". As academics and practitioners we must therefore explore ways in which we could bring the best out of different models so that they can be converged to form a more coherent approach towards the balancing of different conflicting interests.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Shareholder primacy in UK corporate law : an exploration of the rationale and evidence

The aim of the research project described in this report was to examine the rationale for the traditional business objective in the UK which is the maximization of shareholder value (MSV). The project included an analysis of relevant aspects of the Company Law Review (CLR) process in the UK which ultimately led to the Companies Act 2006 (CA 2006) and which determined that shareholder primacy would be maintained as a key principle of UK company law. The CLR had raised the central question: ‘in whose interests should companies be run?’ and put forward two alternatives: one based on shareholder primacy, and the other based on balancing the interests of a range of stakeholders. The two alternatives were described as ‘enlightened shareholder value’ and ‘pluralism’. Specific objectives of this research report included a review of the relevant literature; a study of the official documentation issued in connection with the CLR insofar as this related to the question ‘in whose interests should companies be run?’; an examination of contemporaneous views and debate about the CLR process by studying media coverage of the issues; and ascertaining the views of key individuals who carried out the CLR about how the central question of ‘interests’ was considered, and about the evidence that was used as the basis for its recommendations. The main findings of the report are based on interviews held with 15 individuals, most of whom were directly involved in the CLR, as well as evidence from the literature. The CLR was generally seen as a useful tidying up and modernising exercise; it was also widely thought to have been very ably led. But one of the most striking findings from these interviews was the frustration and strength of feeling about the real value of the CLR exercise amongst some of those who were closely involved. Regarding its consideration of the central debate between enlightened shareholder value and pluralism, the CLR was described as a ‘waste of time’ by one Steering Group member who thought that there was never any intention to have a ‘meaningful discussion of the issues’ while another Steering Group member said there was little interest in discussion of principles or ‘the bigger picture’. Other participants took a quite different view: it appeared to the researchers that those who supported the ‘enlightened shareholder value’ outcome were generally content about the quality of the examination which took place, while those who leaned to the ‘pluralist’ view, which was rejected, were very much less so. Having said that, a number of interviewees, even some who were supportive of its outcomes, felt that the breadth of expertise and opinion represented on the Review was rather narrow; and a more critical view was that it was set up to fail. In response to a question about the evidence that was considered as part of the CLR we gathered that the process was ‘less a matter of evidence and more one of debate’ though it was also suggested that the knowledge and experience brought to the Review by the participants meant that evidence was not lacking. However a very specific criticism was the absence of discussion of comparative international evidence. A detailed consideration of differing types of capitalism, including the significance of legal traditions, is a feature of the literature review in this report. A key part of that review is the description of two competing approaches to capitalism which are widely acknowledged. One approach, the Anglo-American, is found in the developed English speaking countries, and is sometimes characterised as ‘stock market capitalism’, in contrast to what may be called ‘social market’ capitalism which can be found, in differing forms, in continental Europe and in Japan. Arguably the central feature which distinguishes these two approaches is the objective which companies pursue. In the Anglo-American countries this is typically MSV, while traditionally in the other group a balance is struck between the interests of different stakeholder groups. Thus the two approaches may be characterised as ‘shareholder value’ and ‘stakeholder’ capitalism respectively, corresponding to the alternatives presented by the CLR. It is also worth noting that, within the literature and in the business media, there have been calls for the ‘shareholder value’ model to be adopted in what have traditionally been ‘stakeholder’ countries; though such arguments have also been strongly challenged. Interviewees were asked about the new wording for directors’ duties introduced by CA 2006. This wording requires directors to ‘promote the success of the company for the benefit of its members’ while having regard to the interests of others. This form of wording is regarded by some as giving more acknowledgment to the interests of stakeholders (other than shareholders) than the wording it replaced. However there is also a view that it does the opposite. Since the old wording referred to ‘the company’ rather than members, the new wording is seen by some as making shareholder primacy more explicit. The wording was summed up as ‘a fudge’ by one of our interviewees. What was made very clear to us was that shareholder primacy was the intended outcome – and this was the unequivocal understanding of all the interviewees. Interviewees were asked whether directors’ duties amounted to a duty to maximise shareholder value and broadly speaking this was agreed. While there were differing views over whether this meant maximising share price in the short term, interviewees from the corporate sector thought that this was exactly what it meant. Some interviewees questioned the importance of the legal wording on directors’ duties and noted that shareholder value rhetoric in the US and UK was a result of pressure from the financial markets rather than legal requirements. But it was also thought that a ‘shareholder primacy legal framework’ readily lent itself to a shareholder value rhetoric whose emphasis on a single financial metric was implicated in the phenomenon of ‘financialisation’, and specifically in high levels of executive remuneration and the financial crisis. In relation to differing forms of capitalism, interviewees did recognise MSV and shareholder primacy as identifying characteristics of Anglo-American capitalism though some interviewees were also quick to point out some differences between the US and UK. Evidence that poorer societal well-being is associated with the Anglo-American model of capitalism was presented to interviewees for their reaction. Such evidence is extensive and shows that a range of health and other “quality of life” indicators are highly correlated with income inequality. Amongst the developed OECD countries higher inequality is associated with countries which have traditionally followed a “shareholder value” rather than a “pluralist” approach to business objectives. In particular, interviewees were asked whether such evidence could be considered relevant to any review of the laws governing corporate conduct. Views varied a great deal; some were skeptical about the evidence and some were not, but most interviewees thought that the evidence merited serious consideration in any future review of the legal framework governing companies

Nonlinear Analysis of the Eckhaus Instability: Modulated Amplitude Waves and Phase Chaos with Non-zero Average Phase Gradient

We analyze the Eckhaus instability of plane waves in the one-dimensional complex Ginzburg-Landau equation (CGLE) and describe the nonlinear effects arising in the Eckhaus unstable regime. Modulated amplitude waves (MAWs) are quasi-periodic solutions of the CGLE that emerge near the Eckhaus instability of plane waves and cease to exist due to saddle-node bifurcations (SN). These MAWs can be characterized by their average phase gradient $\nu$ and by the spatial period P of the periodic amplitude modulation. A numerical bifurcation analysis reveals the existence and stability properties of MAWs with arbitrary $\nu$ and P. MAWs are found to be stable for large enough $\nu$ and intermediate values of P. For different parameter values they are unstable to splitting and attractive interaction between subsequent extrema of the amplitude. Defects form from perturbed plane waves for parameter values above the SN of the corresponding MAWs. The break-down of phase chaos with average phase gradient $\nu$ > 0 (``wound-up phase chaos'') is thus related to these SNs. A lower bound for the break-down of wound-up phase chaos is given by the necessary presence of SNs and an upper bound by the absence of the splitting instability of MAWs.Comment: 24 pages, 14 figure

Political polarization of news media and influencers on Twitter in the 2016 and 2020 US presidential elections

Social media has been transforming political communication dynamics for over a decade. Here using nearly a billion tweets, we analyse the change in Twitter’s news media landscape between the 2016 and 2020 US presidential elections. Using political bias and fact-checking tools, we measure the volume of politically biased content and the number of users propagating such information. We then identify influencers—users with the greatest ability to spread news in the Twitter network. We observe that the fraction of fake and extremely biased content declined between 2016 and 2020. However, results show increasing echo chamber behaviours and latent ideological polarization across the two elections at the user and influencer levels

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial

<p>(<b>A</b>) Immunofluorescence signal for dystrophin is significantly reduced in the SSI heart (bottom left panel) compared with the immunofluorescent signal in the SHAM heart (upper left panel), and the SHAM+ALLN (upper right panel) and SSI+ALLN (bottom right panel) myocardium. (<b>B</b>) Protein levels of dystrophin in the SHAM, SSI, SHAM+ALLN and SSI+ALLN hearts were measured 24 h after the CLP procedure and were expressed in arbitrary units (AUs). α-Tubulin was used to determine equivalent loading conditions. The results (n = 6 per group) are representative of three different experiments. Scale bars indicate 50 μm.</p

Nonlinear Modulation of Multi-Dimensional Lattice Waves

The equations governing weakly nonlinear modulations of $N$-dimensional lattices are considered using a quasi-discrete multiple-scale approach. It is found that the evolution of a short wave packet for a lattice system with cubic and quartic interatomic potentials is governed by generalized Davey-Stewartson (GDS) equations, which include mean motion induced by the oscillatory wave packet through cubic interatomic interaction. The GDS equations derived here are more general than those known in the theory of water waves because of the anisotropy inherent in lattices. Generalized Kadomtsev-Petviashvili equations describing the evolution of long wavelength acoustic modes in two and three dimensional lattices are also presented. Then the modulational instability of a $N$-dimensional Stokes lattice wave is discussed based on the $N$-dimensional GDS equations obtained. Finally, the one- and two-soliton solutions of two-dimensional GDS equations are provided by means of Hirota's bilinear transformation method.Comment: Submitted to PR

Constructing a bivariate distribution function with given marginals and correlation: application to the galaxy luminosity function

We show an analytic method to construct a bivariate distribution function (DF) with given marginal distributions and correlation coefficient. We introduce a convenient mathematical tool, called a copula, to connect two DFs with any prescribed dependence structure. If the correlation of two variables is weak (Pearson's correlation coefficient $|\rho| <1/3$), the Farlie-Gumbel-Morgenstern (FGM) copula provides an intuitive and natural way for constructing such a bivariate DF. When the linear correlation is stronger, the FGM copula cannot work anymore. In this case, we propose to use a Gaussian copula, which connects two given marginals and directly related to the linear correlation coefficient between two variables. Using the copulas, we constructed the BLFs and discuss its statistical properties. Especially, we focused on the FUV--FIR BLF, since these two luminosities are related to the star formation (SF) activity. Though both the FUV and FIR are related to the SF activity, the univariate LFs have a very different functional form: former is well described by the Schechter function whilst the latter has a much more extended power-law like luminous end. We constructed the FUV-FIR BLFs by the FGM and Gaussian copulas with different strength of correlation, and examined their statistical properties. Then, we discuss some further possible applications of the BLF: the problem of a multiband flux-limited sample selection, the construction of the SF rate (SFR) function, and the construction of the stellar mass of galaxies ($M_*$)--specific SFR ($SFR/M_*$) relation. The copulas turned out to be a very useful tool to investigate all these issues, especially for including the complicated selection effects.Comment: 14 pages, 5 figures, accepted for publication in MNRAS